Automated Construction of Mesoscopic Railway Infrastructure Models Supporting Station Throat Capacity Assessment

Assessment of the traffic capacity of a rail infrastructure involved within railway stations is one of the basic components of the rail transport planning process.An important part of the rail infrastructure in the stations is station throat, which typically comprises many switches and track crossings.Station throat acts as operating bottleneck tha

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Coupling of autophagy and the mitochondrial intrinsic apoptosis pathway modulates proteostasis and ageing in Caenorhabditis elegans

Abstract Mitochondria preserve metabolic homeostasis and integrate stress signals, to trigger cytoprotective, or cell death pathways.Mitochondrial homeostasis and function decline with age.The mechanisms underlying the deterioration of mitochondrial homeostasis during ageing, or in age-associated pathologies, remain unclear.Here, we show that CISD-

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